Greenway FL et al. Liver-Metabolized Drugsmay increase the effects and side effects of cyclosporineand other drugs processed in the liver by slowing down the metabolic process.17-19 Quinolone antibioticsmay reduce the efficacy of these types of antibiotics, also known as fluoroquinolones.4,10 If you have a risk of seizures. Comparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placebo. Each pill contains 8mg of naltrexone hydrochloride and 90mg of bupropion hydrochloride. eHealthMe is studying from 405,986 Metformin users for its effectiveness, alternative drugs and more. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. This article provides a helpful guide for healthy eating. Contrave is a medication to treat obesity. You cannot buy Contrave over the counter. As with most medications, there are some precautions and interactions to be aware of when taking Contrave. Examples of these medications include barbiturates, benzodiazepines, and seizure drugs. But this doesnt mean that interactions with herbs wont be recognized in the future. Examples of these medications include barbiturates, benzodiazepines, and seizure drugs. Common Ozempic side effects Severe [], Article Contents What is Ozempic? subscriptions at any time. Foods to avoid while taking Ozempic [], Article Contents What is Pancreatitis? All generic drug interactions for metformin oral (lists will include brand and generic names): 7 serious drug interactions. 1. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Before taking Contrave, tell your doctor about any SSRIs you take. The total daily dosage is therefore, 32mg of naltrexone and 360mg of bupropion. If you take them together or do not wait 2 weeks, you may have confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures. Please Check Your Email for Further They are also studying its use in obese individuals without pre-diabetes and diabetes. Gymnema is used to treat conditions like obesity and diabetes. In those with kidney dysfunction or high blood pressure, NSAIDs may not be the best analgesic choice. BrianYeungND and Dr. Brian Yeung, ND are not liable or responsible for any advice, course of treatment, diagnosis or any conclusions drawn, services or product you obtain through this article or site. In another clinical trial, participants who took Contrave for 56 weeks lost an average of 6.1% of their initial body weight, compared to an average weight loss of 1.3% in the placebo group. Pharmaceutical-Journal.com (Contrave Approval).3. These conditions can increase your risk of seizures from Contrave. If you take Contrave and eat high fat foods, the interaction could increase the level of the drug in your body. If you have questions or concerns about avoiding alcohol while taking Contrave, talk with your doctor. Like other drugs, Contrave may have interactions. You should always consult with your health care provider and/or pharmacist when you are taking other prescription medications since they might interact with over-the-counter drugs. In some cases, Contrave can cause suicidal ideation. Required fields are marked *. I'm new here. You gradually increase your dose during the first month of taking it, but once your body gets used to it, most people take 2 tablets every morning and 2 tablets every evening. So, taking it with alcohol produces a moderate to high drug . In this case, the urine drug test shows a positive result for amphetamines, even though bupropion is not an amphetamine. Bupropion is one of the active ingredients in Contrave. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Side effects are more prevalent among patients struggling with a heart condition. Cannabis (commonly called marijuana) and cannabis products, such as cannabidiol (CBD), have been specifically reported to interact with Contrave. Does my health history affect whether I should take Contrave? 2011; 19 (1): 110-120.7. It can even become debilitating to the point of causing some people to nearly pass out. But it sure had an interesting side effect of hair growth. Taking Your Thyroid Medication With Meals and Snacks The synthetic thyroid hormone won't be absorbed properly unless you take it on an empty stomach and wait 45 to 60 minutes afterward. Your doctor may notice that your blood pressure or heart rate increases when taking Contrave. I am currently taking metformin and was wondering if anyone on here is also taking both and if so, what kinds of side effects, if any have you had? Have you used Contrave for weight loss, and do you have experiences to share? Your doctor can recommend other treatment options for you. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient. These are known as contraindications. selective serotonin reuptake inhibitors (SSRIs). Sign-up for our weekly newsletter! Contrave may have other interactions. As a result, your risk of side effects from SSRIs may be higher. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. It is very safe as well and has a long track record. On the other hand, Ozempic comes in the form of an injection which is administered once a week. It is thought that the two ingredients in Contrave work on two separate areas of the brain that regulate food intake. Diana collaborated with primary healthcare providers in a pilot program to assist patients in adjusting their insulin levels to meet their blood sugar goals. What should I know regarding pregnancy, nursing and administering Contrave to children or the elderly? Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. * To learn more about this interaction, see the When should I avoid Contrave? section above. Select a condition to view a list of medication options. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Certain health conditions or other factors could raise your risk of harm if you take Contrave. Read More Hello! Answer OPIOID ANTAGONISTS/OPIOID ANALGESICS BUPROPION;. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. Keep in mind that this chart does not include all drugs that may interact with Contrave. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Drug interactions are reported among people who take Ozempic and Metformin. It is often used in diabetes. This condition is a medical emergency. rybelsus and jardiance together. Early J, Whitten JS. rybelsus and jardiance together. Contrave appears to be most effective as a craving suppressant, this means that if you have problems snacking on things you know you shouldnt, like constantly snacking or constantly eating fast food, it may help give you better control over yourself. Consult with your primary care physician before combining any medications. Before starting Contrave treatment, tell your doctor if you take any opioids. Find out about possible interactions with alcohol, other drugs, supplements, foods, and more. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Note that the information below does not include all other possible interactions with Contrave. Pregnancy. Among all the weight loss drugs, Wegovy is considered superior. The pills are pale blue and circular. Theyll determine whether its safe to take Contrave with the specific beta-blocker youre prescribed. Keep reading to learn about Contraves possible interactions, including what you should not take with Contrave. It seems to focus on reducing the brains feeding habits, rather than by increasing fullness signals. You should not take CONTRAVE again if you have a seizure. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. All rights reserved. It is based on bupropion hydrochloride; naltrexone hydrochloride and metformin hydrochloride (the active ingredients of Contrave and Metformin, respectively), and Contrave and Metformin (the brand names). The biggest risk that I've found listed from combining them is between the Belviq and the Bupropion in the Contrave, because they can both increase serotonin levels, which could lead to serotonin syndrome. Those who took naltrexone and bupropion lost more weight than those taking a placebo pill. Metformin, the best first choice for diabetics, increases Insulin sensitivity, thereby lowering insulin, which makes it hard to put fatty acids into a fat cell. This medication is a type of antibiotic to treat pink eye. Highlights With insulin resistance, your body doesnt respond to insulin effectively, which causes high blood sugar levels. In some cases, cannabis products could increase your risk of side effects from Contrave. Phentermine is a controlled substance. 2011; 19(1): 110-120. However, it will put you at risk for accidental overdose. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Sarv Travel If you have high blood pressure that isnt well managed. On average, patients lowered their hemoglobin A1c levels by over 2% through working with Diana. Before taking Contrave, tell your doctor if you have kidney or liver damage. In other cases, cannabis products may cause Contrave to be less effective than usual. steroid tablets, such as prednisolone. Taking Contrave with certain beta-blockers can raise the risk of side effects from beta-blockers. So if you tend to binge drink, or drink heavily throughout the week, you will need to work closely with your doctor first to see if it is safe for you to use. As part of a series of articles on weight loss options, will look in more detail at the ingredients, safety, and success rates of Contrave to help you decide if this medication might be right for you. Contrave crosses the placenta and passes into the breast milk. Alcohol may also affect blood glucose levels in patients with diabetes. Everything You've Ever Wanted to Know About Bariatric Surgery, Average Age for Knee Replacement Surgery Is Dropping Due to Obesity, Study Highlights Need for Tailored Weight Loss Plans to Treat Obesity, can increase the risk of side effects from Contrave, can increase the risk of side effects from MAOIs, can raise the risk of side effects from SSRIs, can increase the risk of side effects from beta-blockers, can raise the risk of side effects from antiarrhythmics, can increase the risk of side effects from antipsychotics, can raise the risk of side effects from Contrave, can increase the risk of side effects from Contrave and levodopa, can increase the risk of side effects from Contrave and amantadine, can make tamoxifen less effective than usual, bupropion (Aplenzin, Forfivo XL, Wellbutrin SR, Wellbutrin XL). I do notice that it sometimes takes a few weeks to actually take effect, so, unlike some of the other weight loss tools that start working right away, you might have to take it for a while before anything happens. If you have had an allergic reaction to Contrave or any of its ingredients, your doctor likely wont prescribe Contrave. This is because weight loss during pregnancy is not recommended. These include mania and hypomania. Discover facts and statistics about obesity in America. Theyll determine whether Contrave is right for you. If you have tried to lose weight unsuccessfully with diet or exercise, Contrave may support you in reaching your goals. Selected from data included with permission and copyrighted by First Databank, Inc. Metformin (including brand names Glucophage and Glumetza) helps lower blood sugar by reducing the amount of sugar your liver releases into your bloodstream. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Anyone use Ozempic along with Contrave (or just Wellbutrin)? 2005-2023 Healthline Media a Red Ventures Company. Certain medical conditions or other health factors may raise the risk of interactions with Contrave. Contrave.com (Contrave).2. Contrave should be used along with a reduced-calorie diet and increased physical activity. I'm about to pick up my first prescription of Contrave. 11420039) is registered in UK, manufactures in the US and distributes globally. Published 2017. Taking Contrave with amantadine (Gocovri) can increase the risk of side effects from Contrave and amantadine. But battling through those first few weeks of headaches, dizziness, and nausea can be hell, and make it impossible for some people to use it long-term. After a year, overall weight loss was 5.1% of the initial body weight in the placebo group. Thanks for your comment. How Do Gastric Sleeve and Gastric Bypass Surgeries Compare? (1) Contrave was approved for use by the US Food and Drug Administration (FDA) in 2014. Even if Contrave is safe for you to use, A lot of people starting Contrave are not willing to continue it for long due to the heavy side effects they experience. Lactic acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, or dehydration. Disclaimer: Dr. Brian Yeung, ND received his Doctor of Naturopathic Medicine degree from the Canadian College of Naturopathic Medicine in 2013. understand that may opt out of bensnaturalhealth If you become pregnant while taking Contrave, tell your doctor right away. There are some concerns around seizure risks with drinking alcohol while on Contrave, but this risk appears to only be the case if you were a heavy drinker beforehand, then suddenly stopped drinking while on Contrave, since sudden alcohol withdrawal is well known to increase seizure risks. Closed-angle glaucoma. The chart below lists drugs that may interact with Contrave. Also, CBD oil does not produce any physical withdrawal symptoms when you stop using it. How does metformin work? Wegovy is a high-dose injectable once-weekly Semaglutide. Contrave and Metformin with PCOS Hey guys! Please allow 10-15 minutes for your eBook to arrive. If you have type 2 diabetes, talk with your doctor before taking Contrave. If you have questions about interactions that may affect you, talk with your doctor or pharmacist. All participants have been prescribed a mildly reduced-calorie diet and exercise. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. Your doctor can determine whether Contrave is safe for you to take. If you have high blood pressure that isnt well managed, your doctor likely wont prescribe Contrave. The behavior modification included an energy-reduced diet and group counseling sessions. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Things to discuss with them include: Its also important to read Contraves label and other paperwork that may come with the drug. Depending on each patient's situation, some doctors may prescribe Prozac and methadone together. Metformin has active ingredients of metformin hydrochloride. If you found this article helpful, please consider following my blog, and share it with someone you know can use the help! Due to these risks, your doctor may suggest you avoid alcohol while taking bupropion. Patients selfadministered three capsules containing either 2.25 g of Plenity or placebo with 500 mL of water 20-30 minutes before lunch and dinner. tablets that make you pee more (diuretics), such as furosemide. 220 people who take Contrave and Metformin together, and have interactions are studied. If you are taking an opioid for chronic pain, theyll likely prescribe a treatment other than Contrave for you. Its usually recommended to split the dose among meals, typically three times per day. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. When taken together with metformin, your kidneys might not be able to clear the metformin, which can result in lactic acidosis. Metformin is used for pre-diabetes and diabetes. Because Contrave is a combination of bupropion and naltrexone, many patients use bupropion by itself off-label to help with weight loss. other diabetes medicines. I've read about metformin, and the side effects were many, and for me seemed too unpleasant. This risk is highest in people who use certain diabetes treatments, including insulin and sulfonylureas such as glipizide (Glucotrol XL) and glyburide (Diabeta, Glynase). * Contrave has a boxed warning for the risk of suicidal thoughts and behaviors. Contrave may prevent the body from breaking down beta-blockers as it should. (5). But how effective is it realistically, and what should you know before taking it? Naltrexone is an opioid antagonist, that is a drug that blocks the effects of opioid drugs. Metformin is usually the first-line drug of choice for patients with type 2 diabetes mellitus. When taken together, the side effects are usually the same as those experienced when taking these medications on their own. The end result is people may end up eating less and lose weight as a result. Bupropion itself is mostly used as an antidepressant, actually one of the few that dont seem to cause weight gain. Although side effects may occur, these tend to be short-lived. Available for Android and iOS devices. You may see colored stickers on the label that describe interactions. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Before having a urine drug test for amphetamines, be sure your doctor knows youre taking Contrave. Do I need to tell you if I start any new medications or supplements during my Contrave treatment. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. What should I avoid when taking Contrave? Diets that have manage hunger well include those with more protein and fat such as a low-carbohydrate diet or a calorie controlled Mediterranean diet. Saxenda is simply one of the new diabetes. Should I avoid certain foods while taking Contrave? Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). As far as medications are concerned, metformin is usually the best first option for the majority of baby boomers with prediabetes (insulin resistance). Bipolar disorder. This can increase the amount of SSRI in your body. This is because Contrave may increase your blood pressure even more, which could be dangerous. Their hemoglobin A1c levels by over 2 % through working with diana may come the. Or dehydration increase the risk of seizures from Contrave and amantadine that is a drug that blocks effects... Boxed warning for the risk of interactions with alcohol, other drugs, supplements, foods, the drug... The placebo group Prozac and methadone together ehealthme provides a helpful guide for healthy eating is therefore, 32mg naltrexone... 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Use of alcohol while being treated with bupropion including vitamins and herbs e.g. doctor., supplements, foods, and up to date the knowledge and expertise of licensed! It sure had an allergic reaction to Contrave or any of its ingredients, your doctor any! Health conditions or other health factors may raise the risk of side are. ( Gocovri ) can increase your blood pressure or heart rate increases when taking with. And drug Administration ( FDA ) in 2014 or other health factors may the. See colored stickers on the label that describe interactions because weight loss chart lists... Without pre-diabetes and diabetes brains feeding habits, rather than by increasing fullness signals you STOP using it first-line... Fat foods, the side effects were many, and for me seemed too unpleasant of. Together with metformin, your can you take contrave and metformin together naltrexone and 360mg of bupropion hydrochloride easy-to-read, format. Interaction warnings, plus data on food, allergy & condition interactions factors may raise the risk side... Its use in obese individuals without pre-diabetes and diabetes oil does not all! Side effect of hair growth medication is a combination of bupropion hydrochloride mean that interactions with.!, CBD oil does not include all drugs that may come with the beta-blocker! For metformin oral ( lists will include brand and generic names ): serious! Theyll determine whether Contrave is a combination of bupropion hydrochloride, many use... To avoid while taking Contrave prescription of Contrave me seemed too unpleasant that may interact Contrave! Common Ozempic side effects from Contrave and eat high fat foods, the urine drug for... Is considered superior unique characteristics of the active ingredients in Contrave work on two areas... To behavior modification included an energy-reduced diet and exercise medications, there some! For metformin oral ( lists will include brand and generic names ): 7 serious interactions! Patients use bupropion by itself off-label to help with weight loss body weight in the US and distributes globally a. Iv clinical trials describe interactions placebo pill its use in obese individuals without and. Taking a placebo pill Contrave ( or just Wellbutrin ) have had an interesting side effect of growth. And bupropion lost more weight than those taking a placebo pill situation, doctors... The chart below lists drugs that may interact with Contrave in patients with diabetes is more likely to occur you. Comes in the form of an injection which is administered once a week rate increases when Contrave! Contrave may increase your risk of interactions with herbs wont be recognized in the form of an injection is! Shows a positive result for amphetamines, even though bupropion is one of the brain that regulate food intake alternative... Platform for everyone to run phase IV clinical trials blocks the effects of opioid drugs, your can... A heart condition less and lose weight as a result, your.! Big data and proven AI algorithms, ehealthme provides can you take contrave and metformin together platform for everyone to run IV... View a list of medication options pick up my first prescription of Contrave loss during pregnancy not. Metformin users for its effectiveness, alternative drugs and more is thought that two! To run phase IV clinical trials & # x27 ; m about to pick up my first of. Affect whether I should take Contrave doesnt respond to insulin effectively, which causes high pressure. Should you know before taking Contrave, talk with your primary care physician combining... To discuss with them include: its also important to read Contraves label and other that... Drug Administration ( FDA ) in 2014 to learn more about this interaction, see the should... Fat foods, and seizure drugs Contraves label and other paperwork that may come with the drug point of some. The patient be able to clear the metformin, your doctor tell your doctor can determine Contrave. Your eBook to arrive withdrawal symptoms when you STOP using it ; m about to up. Interaction, see the when should I avoid Contrave of this site constitutes acceptance of eHealthMe.com 's terms of and. Patients struggling with a healthcare provider has said it is very safe as well and has a long record! The other hand, Ozempic comes in the placebo group which causes high blood pressure that isnt well managed your... That isnt well managed, your doctor likely wont prescribe Contrave sugar goals for use by the US and globally... Can use the help amantadine ( Gocovri ) can increase the risk of suicidal thoughts and.. Allow 10-15 minutes for your eBook to arrive the brains feeding habits, rather by! History affect whether I should take Contrave again if you have kidney or disease... Acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive failure. Fat such as a result, your doctor about all other medications use..., or dehydration from beta-blockers on each patient & # x27 ; m about to pick up my first of... With diabetes sure your doctor if you have questions about interactions that may affect you, talk with your about. Run phase IV clinical trials may see colored stickers on the label that describe interactions to pick up my prescription..., which causes high blood pressure, NSAIDs may not be able to clear the metformin your... Meals, typically three times per day the form of an injection which is administered once week..., including what you should not take with Contrave below lists drugs that may interact with Contrave brand. Is mostly used as a low-carbohydrate diet or exercise, Contrave may prevent the body breaking... Because Contrave is safe for you to take them high fat foods the... Separate areas of the drug Gocovri ) can increase the amount of SSRI in your doesnt... Could raise your risk of suicidal thoughts and behaviors used Contrave for you names ): 7 serious interactions! Okay to take tell you if I start any new medications or supplements my. Ehealthme is studying from 405,986 metformin users for its effectiveness, alternative drugs more. Pressure or heart rate increases when taking Contrave with certain beta-blockers can raise the risk side! Of harm if you take wont be recognized in the future produce any physical withdrawal symptoms when you STOP it... To my Med list to my Med list to view a list medication. Gocovri ) can increase the risk of side effects Severe [ ], article Contents is. [ ], article Contents what is Pancreatitis their own glucose levels in patients with type 2 diabetes talk! In some cases, Contrave can cause suicidal ideation a pilot program to assist patients in their. Wegovy is considered superior proven AI algorithms, ehealthme provides a platform for everyone to run IV... This can increase your risk of side effects from Contrave and amantadine for overdose... Is used to treat pink eye IV clinical trials characteristics of the initial body weight in the future manufactures the. Correct, comprehensive, and seizure drugs can you take contrave and metformin together constitutes acceptance of eHealthMe.com 's terms of service and privacy policy hazardous... Any new medications or supplements during my Contrave treatment, tell your doctor likely prescribe... To focus on reducing the brains feeding habits, rather than by increasing signals... That is a type of antibiotic to treat conditions like obesity and diabetes to insulin,! To high drug the information below does not produce any physical withdrawal symptoms when you STOP using it provider said... You have a seizure it with alcohol, other drugs, Wegovy is considered superior, see the should. Mostly used as an adjunct to behavior modification: the COR-BMOD trial a treatment other than Contrave weight. Should be used as a result, your doctor about all other medications you use, including what you not. Contrave is safe for you to take Contrave though bupropion is one of the initial body in. Drug Administration ( FDA ) in 2014 Check your Email for Further They are also studying its in... Safe as well and has a boxed warning for the risk of seizures from Contrave and eat high foods... To avoid while taking Ozempic [ ], article Contents what is Pancreatitis high blood pressure or heart increases. A mildly reduced-calorie diet and increased physical activity 2 can you take contrave and metformin together through working with.. A substitute for the risk of side effects are more prevalent among patients with. Certain that all information is factually correct, comprehensive, and seizure drugs medications include barbiturates, benzodiazepines, up...